Taken from a group home at age twelve, Evan Smoak grew up and qualified as an off-the-books government assassin: Orphan X. After he broke using the Orphan Program, Evan vanished and reinvented himself as the Nowhere Guy, a man discussed only in whispers, reachable just at a secret phone number transferred around by those in want, and dedicated to helping the really desperate.

But this time, the desperate voice over the other end from the line is Jack Johns, the person who raised and trained Evan, the person who is the only dad Evan has ever known. Magic formula government causes are busy looking to scrub the rest of the survivors of the Orphan Program, and they have finally monitored down Jack port. With short amount of time remaining, Jack provides Evan his final assignment: discover and defend his last protégé and recruit for this program.

But Evan isn’t the only one after this last Orphan. Evan’s deadliest adversary, the brand new head from the Orphan Plan, is mustering every asset at his removal to take out Jack’s final protégé-and eliminate the Nowhere Man forever.