Hellboy comes to a crossroads in Enigma, Georgia, a small town bested simply by strange occurrences. Sent to keep an eye on Sarah Nail, a girl hiding from your curse of her family members, he turns into entangled in the blood debt of evil mystical preacher Sibling Jester. Stuck between human being malice and the mysteries of the occult, Hellboy comes up against an intrigue of ghosts, demon trees, talking bullfrogs, and a race of lost mutant children.