It begins with the murder of a fresh York socialite. Following trail of the killers, Spider-Man is normally soon confronted by one of his oldest, deadliest enemies: the Lizard. Once a reputed scientist, Dr. Curt Connors produced a serum that he hoped would regenerate the arm he previously lost years before. But the serum do a lot more than regrow his arm-it turned him into the savage, human-hating creature known as the Lizard. Spider-Man pursues the Lizard from your cement canyons of New York to the lush jungles of Mexico. Once there, he discovers not just that the Lizard is usually formulating a fresh plan to get rid of all humans but also that he today has an army of reptilian animals ready to carry out his orders!